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The Rewiring Brain: A Computational Approach to Structural Plasticity in the Adult Brain

Edited by Arjen van Ooyen and Markus Butz-Ostendorf
San Diego: Academic Press, 2017
ISBN 978-0-12-803784-3
xviii + 566 pages, 132 illustrations

Cover of Anatomy and Plasticity in Large-Scale Brain Models The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke.

Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. However, most traditional neural network models have fixed neuronal morphologies and a static connectivity pattern, with plasticity merely arising from changes in the strength of existing synapses (synaptic plasticity).

In The Rewiring Brain, the editors bring together, for the first time, contemporary modeling studies that investigate the implications of structural plasticity for brain function and pathology. Starting with an experimental background on structural plasticity in the adult brain, the book covers computational studies on homeostatic structural plasticity, the impact of structural plasticity on cognition and cortical connectivity, the interaction between synaptic and structural plasticity, neurogenesis-related structural plasticity, and structural plasticity in neurological disorders.

Structural plasticity adds a whole new dimension to brain plasticity, and The Rewiring Brain shows how computational approaches may help to gain a better understanding of the full adaptive potential of the adult brain. The book is written for both computational and experimental neuroscientists.

Key features:
• Reviews the current state of knowledge of structural plasticity in the adult brain
• Gives a comprehensive overview of computational studies on structural plasticity
• Provides insights into the potential driving forces of structural plasticity and the functional implications of structural plasticity for learning and memory
• Serves as inspiration for developing novel treatment strategies for stimulating functional repair after brain damage

For a preview and to order the book, go to Elsevier Store or Google Books. To purchase individual book chapters, see ScienceDirect.

Book contents:


List of contributors

Arjen van Ooyen and Markus Butz-Ostendorf
[Full text: PDF]

    Section I. Experimental Background

  1. Structural plasticity and cortical connectivity
    Vassilis Kehayas and Anthony Holtmaat

  2. Structural plasticity induced by adult neurogenesis
    Gregory W. Kirschen, Kurt A. Sailor, and Shaoyu Ge

  3. Structural neural plasticity during stroke recovery
    Kimberly Gerrow and Craig E. Brown

  4. Is lesion-induced synaptic rewiring driven by activity homeostasis?
    Markus Butz-Ostendorf and Arjen van Ooyen
    [Abstract] [Full text: PDF]

    Section II. Homeostatic Structural Plasticity

  5. Network formation through activity-dependent neurite outgrowth: a review of a simple model of homeostatic structural plasticity
    Arjen van Ooyen
    [Abstract] [Full text: PDF]

  6. Clustered arrangement of inhibitory neurons can lead to oscillatory dynamics in a model of activity-dependent structural plasticity
    Rosanna C. Barnard, Istvan Z. Kiss, Simon F. Farmer, and Luc Berthouze

  7. A detailed model of homeostatic structural plasticity based on dendritic spine and axonal bouton dynamics
    Markus Butz-Ostendorf and Arjen van Ooyen

  8. Critical periods emerge from homeostatic structural plasticity in a full-scale model of the developing cortical column
    Sebastian Rinke, Mikaël Naveau, Felix Wolf and Markus Butz-Ostendorf

  9. Lesion-induced dendritic remodeling as a new mechanism of homeostatic structural plasticity in the adult brain
    Steffen Platschek, Hermann Cuntz, Thomas Deller, and Peter Jedlicka

    Section III. Structural Plasticity and Connectivity

  10. The role of structural plasticity in producing nonrandom neural connectivity
    Paul Miller

  11. Structural plasticity and the generation of bidirectional connectivity
    Daniel Miner, Felix Z. Hoffmann, Florence Kleberg, and Jochen Triesch

  12. Spike timing-dependent structural plasticity of multicontact synaptic connections
    Moritz Deger

  13. Selection of synaptic connections by wiring plasticity for robust learning by synaptic weight plasticity
    Naoki Hiratani and Tomoki Fukai

    Sction IV. Structural Plasticity and Learning and Memory

  14. Within a spine's reach
    Will DeBello and Karen Zito

  15. Impact of structural plasticity on memory capacity
    Panagiotis Bozelos and Panayiota Poirazi

  16. Long-term information storage by the interaction of synaptic and structural plasticity
    Michael Fauth, Florentin Wörgötter, and Christian Tetzlaff

  17. Impact of structural plasticity on memory formation and decline
    Andreas Knoblauch

    Section V. Neurogenesis-Related Structural Plasticity

  18. Adult neurogenesis and synaptic rewiring in the hippocampal dentate gyrus
    Arjen van Ooyen, Gertraud Teuchert-Noodt, Keren Grafen, and Markus Butz-Ostendorf

  19. Modifications in network structure and excitability may drive differential activity-dependent integration of granule cells into dentate gyrus circuits during normal and pathological adult neurogenesis
    Quinton Skilling, James Roach, Alison L. Althaus, Geoffrey G. Murphy, Leonard Sander, and Michal Zochowski

  20. Computational perspectives on adult neurogenesis
    Kristofor D. Carlson, Fredrick Rothganger, and James B. Aimone

  21. Restricted boltzmann machine models of hippocampal coding and neurogenesis
    Rory Finnegan, Mark Shaw, and Suzanna Becker

    Section VI. Structural Plasticity and Pathology

  22. Modeling the impact of lesions in the brain
    Sol Lim, Frances Hutchings, and Marcus Kaiser

  23. Network models of epilepsy-related pathological structural and functional alterations in the dentate gyrus
    Ivan Raikov, Mark Plitt, and Ivan Soltesz

  24. Computational models of stroke recovery
    Vittorio Sanguineti

  25. Neural plasticity in human brain connectivity: the effects of deep brain stimulation
    Tim J. van Hartevelt, Henrique M. Fernandes, Angus B. A. Stevner, Gustavo Deco, and Morten L. Kringelbach

For a preview and to order the book, go to Elsevier Store or Google Books. To purchase individual book chapters, see ScienceDirect.
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